NATO: Dette århundredes globo-cop?

GPR40: Good Cop, Bad Cop?

Since its deorphanization in 2003 (1,2), the fatty acid receptor GPR40 (FFAR1/FFA1) has drawn considerable attention as a potential therapeutic target for type 2 diabetes. Because fatty acids acutely amplify insulin secretion only in the presence of glucose, the discovery of a “drugable” cell surface receptor whose activation glucose-dependently enhances insulin release generated much interest ...

p53 Good Cop/Bad Cop

Activation of the p53 transcription factor in response to a variety of cellular stresses, including DNA damage and oncogene activation, initiates a program of gene expression that blocks the proliferative expansion of damaged cells. While the beneficial impact of the anticancer function of p53 is well established, several recent papers suggest that p53 activation may in some circumstances act i...

Cognitive Radio in NATO

NATO ASI Series

A series presenting the results of activities sponsored by the NA TO Science Committee, which aims at the dissemination of advanced scientific and technoiogicai knowiedge, with a view to strengthening links between scientific communities. Recent Volumes in this Series Volume 181—Fundamental Processes of Atomic Dynamics edited by J. No part of this book may be reproduced, stored in a retrieval s...

Good Cop, Bad Cop: Forcing Middleboxes to Cooperate

The original Internet architecture offered a clean contract to endpoints: packets sent will be delivered unmodified 1 or dropped when there is congestion. The proliferation of middleboxes has broken this simple contract to the point where the service the Internet provides to endpoints is entirely unpredictable: • Reachability depends on fields in the packet header and even the payload, as firew...